MOTS-C (Mitochondrial-Derived Peptide)

Overview

MOTS-C is a mitochondrial-derived peptide consisting of 16 amino acids, naturally produced by mitochondria, which play a crucial role in cellular energy regulation. Unlike traditional peptides, MOTS-C is encoded by mitochondrial DNA (mtDNA), giving it unique metabolic functions. It has gained attention for its ability to regulate metabolic homeostasis, improve insulin sensitivity, and promote fat oxidation, making it a potential therapeutic agent for conditions like obesity, diabetes, and age-related metabolic decline.

MOTS-C Mechanism of Action

MOTS-C acts primarily by targeting and regulating metabolic pathways involved in glucose metabolism and fat oxidation. It mimics the effects of exercise by activating the AMPK (AMP-activated protein kinase) pathway, which promotes glucose uptake by cells and enhances fatty acid oxidation. This action improves insulin sensitivity and helps regulate blood sugar levels.
MOTS-C also counteracts age-related insulin resistance and metabolic dysfunction by modulating pathways involved in mitochondrial function and stress response, potentially extending cellular longevity and improving energy utilization.

Increased glucose metabolism: Promotes glucose uptake by skeletal muscle, improving insulin sensitivity.
Fat oxidation: Enhances the breakdown of fats for energy, leading to reduced fat storage.
Anti-aging effects: Protects cells from metabolic stress and may reduce age-related metabolic disorders.

MOTS-C Dosage

MOTS-C is typically administered as a subcutaneous injection, with dosages ranging from 5 mg to 10 mg, usually taken daily or several times per week depending on treatment objectives (e.g., metabolic enhancement, fat loss, or age-related interventions).

MOTS-C Side Effects

MOTS-C is generally well-tolerated, but some potential side effects may include:

Mild pain or redness at the injection site.
Fatigue, headaches, or slight dizziness.
Temporary fluctuations in blood glucose levels.

MOTS-C Interactions

MOTS-C may interact with other treatments targeting metabolic pathways, such as insulin-sensitizing medications or other peptides that influence mitochondrial function (e.g., AMPK activators). Caution should be taken when combined with glucose-lowering drugs to avoid hypoglycemia.