Aromatase Inhibitors

Aromatase Inhibitor Examples

Aromatase inhibitors are a class of drugs that have revolutionized the treatment of hormone receptor-positive breast cancer in postmenopausal women. The three primary aromatase inhibitors include letrozole, anastrozole, and exemestane, all of which offer a range of benefits to patients.

Letrozole Mechanism Of Action

Letrozole, available in the form of letrozole tablets, is a potent and highly selective nonsteroidal aromatase inhibitor. Its primary benefit is that it effectively reduces estrogen levels in the body by inhibiting the aromatase enzyme, responsible for converting androgens to estrogens. This reduction in estrogen levels starves hormone receptor-positive breast cancer cells of their growth-promoting stimulus, leading to cancer cell death and disease regression.

Anastrozole Mechanism Of Action

Anastrozole, another nonsteroidal aromatase inhibitor, is equally effective in lowering estrogen levels, offering similar benefits to letrozole. It has been shown to improve disease-free survival rates and reduce the risk of cancer recurrence in patients who have undergone surgery or radiation therapy.

Exemestane Mechanism Of Action

Exemestane, a steroidal aromatase inhibitor, works differently than letrozole and anastrozole by irreversibly binding to the aromatase enzyme. This permanent inactivation results in a sustained decrease in estrogen production, offering long-lasting benefits to patients.

In addition to prescription medications, there are aromatase inhibitors supplements available, which can provide a natural alternative for individuals seeking to maintain hormonal balance. These supplements may help in the management of estrogen-sensitive conditions and promote overall health.